Variations in the Piperine content in three varieties of Pepper and mapping its anti-inflammatory potential by molecular docking

Pepper known as the king of spices is one most widely used spice in world, and it has its fair share medicinal properties well. It been traditional medicine for many centuries owing to apart from flavour pungent taste. Piperine important bioactive compound present different Piper species. Differences among three species common South India viz. <i>Piper nigrum</i>, longum</i>, cubeba</i> were evaluated by estimating various phytochemicals such alkaloids, flavonoids, phenols them. Further, quantity piperine these <i>Piper</i> determined using HPLC analysis. The content found be 235.05 μg/mL, 268.50 8.56 μg/mL respectively. Since inflammation major pathology involved disease conditions since pepper traditionally managing respiratory inflammation, we ventured identify anti-inflammatory potential. Herein, checked silico docking analysis with inflammatory proteins. interaction <i>NF</i>-κB, COX-2, COX-1, <i>TNF</i>-α, evidenced binding scores reveals that interacts them modulates inflammation. Further <i>in-vitro</i> in-vivo studies are warranted scientifically validate claims.